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Do not take Calmful Sleep before operating a vehicle or heavy machinery. Calmful Sleep includes melatonin, which may cause drowsiness.

Melatonin supplements can interact with various medications, including blood-thinning medications (anticoagulants), medications that suppress the immune system (immunosuppressants), diabetes medications and birth control pills. Consult a physician if you are currently taking medications and wish to use Calmful Sleep.

Mild gastrointestinal symptoms and rare allergic reactions have been known to occur, in which case, discontinue use.